YU-IOB CSBMM
Sailu Yellaboina, Ph.D.

Associate professor


Biography

Dr. Sailu Yellaboina’s received Master’s Degree in Biochemistry from University of Hyderabad and Doctoral Degree in Computational Biology from Centre for DNA Fingerprinting and Diagnostics (CDFD). After completion of his PhD, he worked as a postdoctoral fellow at National Institutes of Health, from the duration of June 2006 to June 2011. From July 2011 to March 2016, he worked as visiting Associate Professor in CR Rao AIMSCS, University of Hyderabad Campus, Hyderabad and currently he Visiting Associate Professor there. Dr. Sailu Yellaboina’s research interests are integrating massive data coming from diverse technological platforms, cell types and tissues to prioritize genes and networks responsible for desease and cellular phenotypes. While working at CDFD, he has developed computational methods for prediction of regulons and genome-wide protein interactions. During his postdoctoral fellowship at NIH, he developed an integrative framework to combine the genomic datasets to identify the key pathways of ES cell identity and homeostasis. The work ranked the best in Computational Biology study section and was awarded the NIH Fellows Award for Research Excellence in 2010. He has more than 15 publications in peer-reviewed journals such as Molecular Cell, PNAS-USA, Genome Research, Nucleic acids Research and Bioinformatics.

Education
  • Ph.D. in Bioinformatics, Computational Genomics, CDFD, Hyderabad, India, 2005
  • M.Sc. in Medical Biochemistry, University of Hyderabad, India, 1998
  • Positions held
    • Associate professor, YU-IOB Center for Systems Biology and Molecular Medicine, Mangalore, India, 2016 – present
    • Associate professor, CR Rao's Advanced Institute of Mathemetics, Statistics and Computer science, University of Hyderabad, India, 2011-2016
    • Post Doctoral Fellowship, Systems Biology Group, National Institute of Environmental Sciences (NIEHS), National Institutes of Health (NIH), Research Triangle Park, NC, USA, 2009–2011
    • Post Doctoral Fellowship, University of Tennessee Health Science Centre (UTHSC), Memphis, TN, USA, 2008–2009
    • Post Doctoral Fellowship, Laboratory of Genetics, National Institute of Aging, National Institutes of Health (NIH), USA, 2006–2008
    • Project Associate, Structural Biology Group, Centre for DNA Fingerprinting and Diagnostics (CDFD), Hyderabad, India, 2005–2006
    Honors and Awards
    • Best poster award in the conference Genomics in Health and Diseases, GHD organized by CIENCIA Publishers, 2014
    • Best poster award in the conference on Genome architecture & cell fate regulation organized by University of Hyderabad and TIFR, 2014.
    • Travel grant awarded to attend Young Investigators meeting, 2011
    • Visiting Fellowship by National Institutes of Health(NIH, NIEHS), 2009 - 2011
    • Fellows Award for Research Excellence, 2010. (FARE) for outstanding scientific research at NIH
    • Visiting Fellowship by National Institutes of Health (NIH, NIA), 2006 - 2008
    • Travel grant awarded by the Department of Biotechnology, India, 2003
    • Qualified CSIR (Council of Scientific and Industrial Research) exam, Life Sciences/ Recipient of a 5-year fellowship from CSIR for pursuing a career in scientific research
    • Qualified ICAR (Indian Council for Scientific and Agricultural Research) - National Eligibility Test for Lectureship in Animal Biochemistry
    • Qualified Graduate Aptitude Test in Engineering
    Publications

    Research papers: ; Review articles: ; Book Chapters:

    • Akter, Y., Yellaboina, S., Farhana, A., Ranjan, A., Ahmed, N. & Hasain, S. E. (2008). Genome scale portrait of cAMP-receptor protein (CRP) regulons in mycobacteria points to their role in pathogenesis. Gene, 407, 148-158. [PubMed]
    • Arun, P. V., Miryala, S. K., Chattopadhya, S., Thiyyagura, K., Bawa, P., Bhattacharjee, M. & Yellaboina, S. (2016). Identification and functional analysis of essential, conserved, housekeeping and duplicated genes. Febs Letters, 590, 1428-1437. [PubMed]
    • Prakash, P., Yellaboina, S., Ranjan, A. & Hasain, S. E. (2005). Computational prediction and experimental verification of novel IdeR binding sites in the upstream sequences of Mycobacterium tuberculosis open reading frames. Bioinformatics, 21, 2161-2166. [PubMed]
    • Ranjan, S., Seshadri, J., Vindal, V., Yellaboina, S. & Ranjan, A. (2006). iCR: a web tool to identify conserved targets of a regulatory protein across the multiple related prokaryotic species. Nucleic acids research, 34, W584-587. [PubMed]
    • Ranjan, S., Yellaboina, S. & Ranjan, A. (2006). IdeR in mycobacteria: from target recognition to physiological function. Critical Reviews in Microbiology, 32, 69-75. [PubMed]
    • Yellaboina, S., Dudekula, D. B. & Ko, M. (2008). Prediction of evolutionarily conserved interologs in Mus musculus. BMC Genomics, 9, 465.
    • [PubMed]
    • Yellaboina, S., Goyal, K. & Mande, S. C. (2007). Inferring genome-wide functional linkages in E. coli by combining improved genome context methods: comparison with high-throughput experimental data. Genome Research, 17, 527-535. [PubMed]
    • Yellaboina, S., Ranjan, S., Chakhaiyar, P., Hasnain, S. E. & Ranjan, A. (2004). Prediction of DtxR regulon: identification of binding sites and operons controlled by Diphtheria toxin repressor in Corynebacterium diphtheriae. BMC Microbiology, 4, 38. [PubMed]
    • Yellaboina, S., Seshadri, J., Kumar, M. S. & Ranjan, A. (2004). PredictRegulon: a web server for the prediction of the regulatory protein binding sites and operons in prokaryote genomes. Nucleic acids research, 32, W318-320. [PubMed]
    • Yellaboina, S., Tasneem, A., Zaykin, D. V., Raghavachari, B. & Jothi, R. (2011). DOMINE: a comprehensive collection of known and predicted domain-domain interactions. Nucleic acids research, 39, D730-5. [PubMed]
    • Cinghu, S., Yellaboina, S., Freudenberg, J. M., Ghosh, S., Zheng, X., Oldfield, A. J., Lackford, B. L., Zaykin, D. V., Hu, G. & Jothi, R. (2014). Integrative framework for identification of key cell identity genes uncovers determinants of ES cell identity and homeostasis. Proceedings of the National Academy of Sciences, 111, E1581-1590. [PubMed]
    • Freudenberg, J. M., Ghosh, S., Lackford, B. L., Yellaboina, S., Zheng, X., Li, R., Cuddapah, S., Wade, P. A., Hu, G. & Jothi, R. (2012). Acute depletion of Tet1-dependent 5-hydroxymethylcytosine levels impairs LIF/Stat3 signaling and results in loss of embryonic stem cell identity. Nucleic acids research, 40, 3364-3377. [PubMed]
    • Hayles, B., Yellaboina, S. & Wang, D. (2010). Comparing transcription rate and mRNA abundance as parameters for biochemical pathway and network analysis. PLoS One, 5, e9908. [PubMed]
    • Oldfield, A. J., YANG, P., Conway, A. E., Cinghu, S., Freudenberg, J. M., Yellaboina, S. & Jothi, R. (2014). Histone-fold domain protein NF-Y promotes chromatin accessibility for cell type-specific master transcription factors. Molecular cell, 55, 708-722. [PubMed]
    • Yellaboina, S., Rajan, S., Vindal, V. & Rajan, A. (2006). Comparative analysis of iron regulated genes in mycobacteria. Febs Letters, 580, 2567-76. [PubMed]