CSBMM
Arun Kumar H. Patil, M.Sc.

Lecturer - Bioinformatics


Biography

Arun H. Patil obtained his M.Sc. degree in Bioinformatics from Sikkim Manipal University. He also obtained a Post Graduate Diploma in Bioinformatics from the Institute of Bioinformatics and Applied Biotechnology, Bangalore. Subsequently, he worked as Research Associate at the same Institute and participated in the analysis of NextGen sequencing (NGS) data obtained from prostate cancer. He is pursuing his Ph.D.degree at the Institute of Bioinformatics in Bangalore and KIIT University in Bubhaneswar, India. He also worked in the Dr. Akhilesh Pandey´s laboratory at Johns Hopkins University in Baltimore, U.S.A to carry out computational analysis and interpretation of proteomics and next-generation sequencing data. He is involved in the analysis of genomic and proteomic data at YU-IOB Center for Systems Biology and Molecular Medicine, Yenepoya University, Mangalore. He is also teaching concepts of bioinformatics and OMICS data analysis to postgraduate and diploma students.

Scientific discipline
  • Bioinformatics and data analysis
  • Genomics, proteomics and metabolomics
  • Development of biological databases
  • Education
  • M.Sc. in Bioinformatics, Sikkim Manipal University, India, 2012
  • Positions held
  • Bioinformatician, Johns Hopkins University School of Medicine, Baltimore, MD, USA
  • Research Associate, Institute of Bioinformatics and Applied Biotechnology (IBAB), Bangalore
  • Honors and Awards
  • Awarded best poster at the 3rd International Conference on Primary Immunodeficiency Diseases, February 21-23, 2015, Chennai, India
  • Presented an invited talk at “Conference on Informatics and Integrative Biology” December 14-16, 2011, Kolkata, India
  • Publications

    Research papers: 22; Review articles: 0; Book Chapters: 0

    • Rajagopalan, P., Nanjappa, V., Patel, K., Jain, A. K., Mangalaparthi, K. K., Patil, A. H., Nair, B., Mathur, P. P., Prasad, T. S. K., Califano, J. A., Sidransky, D., Gowda, H. and Chatterjee, A. (2017). Role of protein kinase N2 (PKN2) in cigarette smoke-mediated oncogenic transformation of oral cells. Journal of Cell Communication and Signaling. In Press.
    • Mol, P., Kannegundla, U., Dey, G., Gopalakrishnan, L., Dammalli, M., Kumar, M., Patil, A., Basavaraju, M., Rao, A., Ramesha, K. P. and Prasad, T. S. K. (2017). Bovine Milk Comparative Proteome Analysis from Early, Mid and Late Lactation in the Cattle Breed, Malnad Gidda (​​Bos indicus​). OMICS: A Journal of Integrative Biology​. ​In ​p​ress​.
    • Nanjappa, V., Sathe, G.J., Jain, A. P., Rajagopalan, P., Raja, R, Subbannayya, T., Patil, A. H., Kumar, P., Prasad, T. S. K., Mathur, P. P., Sidransky, D., Gowda, H. and Chatterjee, A. Investigation of curcumin mediated signaling pathways in head and neck squamous cell carcinoma. Translational Research in Oral Oncology. In press
    • McCall, M. N., Kim. M., Adil, M., Patil, A. H., Lu, Y., Mitchell, C. J., Leal-Rojas, P., Xu, J., Kumar, M., Dawson, V. L., Dawson, T. M., Baras, A. S., Rosenberg, A. Z., Arking, D. E., Burns, K. H., Pandey, A. and Halushka, M. K. (2017). Towards the human cellular microRNAome. Genome Research. [PubMed]
    • Mir, S. A., Renuse, S., Sathe, G., Khan, A. A., Patil, A., Nanjappa, V., Bhat, A. F., Prasad, T. S. K., Giri, K. A., Chatterjee, A. and Harsha H. C. (2017). Altered signaling associated with chronic arsenic exposure in human skin keratinocytes. Proteomics - Clinical Applications. [PubMed]
    • Sreenivasamurthy, S. K., Madugundu, A. K., Patil, A. H., Dey, G., Mohanty, A. K., Kumar, M., Patel, K., Wang, C., Kumar, A., Pandey, A. and Prasad, T. S. K. (2017). Mosquito-borne diseases and Omics: Tissue-restricted expression and alternative splicing revealed by transcriptome profiling of Anopheles stephensi. OMICS: A Journal of Integrative Biology. [PubMed]
    • Advani, J.#, Subbannayya, Y.#, Patel, K., Khan, A. A., Patil, A. H., Jain, A. P., Solanki, H. S., Radhakrishnan, A., Pinto, S. M., Sahasrabuddhe, N. A., Thomas, J. K., Mathur, P. P., Nair, B., Chang, X., Prasad, T. S. K., Sidransky, D., Gowda H., Chatterjee, A. (2017). Long term cigarette smoke exposure and changes in microRNA expression and proteome in non-small cell lung cancer. OMICS: A Journal of Integrative Biology. [PubMed] (# These authors contributed equally to the manuscript)
    • Verma, R., Pinto, S., Patil, A. H., Advani, J., Subba, P., Kumar, M., Sharma, J., Dey, G., Ravikumar, R., Buggi, S., Satishchandra, P., Sharma, K., Suar, M. T., Srikanth, C., Singh, D., Gowda, H., Pandey, A., Gandotra, S. and Prasad, T. S. K. (2017). Quantitative proteomic and phosphoproteomic analysis of H37Ra and H37Rv strains of Mycobacterium tuberculosis. Journal of Proteome Research. 1632-1645. [PubMed]
    • Cutler, J., Tahir, R., Sreenivasamurthy, S., Mitchell, C., Renuse, S., Nirujogi, R. S., Patil, A. H., Heydarian, M., Wong, X., Wu, X., Huang, T., Kim, M., Reddy, K. and Pandey, A. (2017). Differential signaling through p190 and p210 BCR-ABL fusion proteins revealed by interactome and phosphoproteome analysis. Leukemia. [PubMed]
    • Prasad, T. S. K*., Mohanty, A. K*., Kumar, M*., Sreenivasamurthy, S. K*., Dey, G*., Nirujogi, R. S., Pinto, S. M., Madugundu, A. K., Patil, A. H., Advani, J., Manda, S. S., Gupta, M. K., Dwivedi, S. B., Kelkar, D. S., Hall, B., Jiang, X., Peery, A., Rajagopalan, P., Yelamanchi, S. D., Solanki, H. S., Raja, R., Sathe, G. J., Chavan, S. N., Verma, R., Patel, K. M., Jain, A. P., Syed, N., Datta, K. K., Khan, A. A., Dammalli, M., Jayaram, S., Radhakrishnan, A., Mitchell, C. J., Na, C. H., Kumar, N., Sinnis, P., Sharakhov, I. V., Wang, C., Gowda, H., Tu, Z., Kumar, A. and Pandey, A. (2017). Integrating transcriptomic and proteomic data for accurate assembly and annotation of genomes. Genome Research. 27, 133-144. [PubMed]
    • Raja, R., Sahasrabuddhe, N. A., Radhakrishnan, A., Syed, N., Solanki, H. S., Puttamallesh V. N., Balaji S. A., Nanjappa V., Datta, K. K., Babu, N., Renuse, S., Patil, A. H., Izumchenko, E., Prasad, T. S., Chang X., Rangarajan A., Sidransky, D., Pandey, A., Gowda, H. and Chatterjee, A. (2016). Chronic exposure to cigarette smoke leads to activation of p21 (RAC1)-activated kinase 6 (PAK6) in non-small cell lung cancer cells. Oncotarget. 7, 61229-61245. [PubMed]
    • Sathe, G. J., Pinto, S. M., Syed, N., Nanjappa, V., Solanki, H. S., Renuse, S., Chavan, S., Khan, A. A., Patil, A. H., Nirujogi, R. S., Nair, B., Mathur, P. P., Prasad, T. S. K., Gowda, H. and Chatterjee, A. (2016). Phosphotyrosine profiling of curcumin-induced signaling. Clinical Proteomics. 13, 13. [PubMed]
    • Datta, K. K., Patil, A. H., Patel, K., Dey, G., Madugundu, A. K., Renuse, S., Kaviyil, J. E., Nirujogi, R. S., Arunima, A., Daswani, B., Kaur, I., Mohanty, J., Sinha, R., Jaiswal, S., Sivapriya, S., Sonnathi, Y., Chattoo, B. B., Gowda, H., Ravikumar, R. and Prasad, T. S. K. (2016). Proteogenomics of Candida tropicalis - an opportunistic pathogen with importance for global health. OMICS: A Journal of Integrative Biology. 20, 239-247. [PubMed]
    • Radhakrishnan, A., Nanjappa, V., Raja, R., Sathe, G. J., Chavan, S., Nirujogi, R. S., Patil, A., Solanki, H., Renuse, S., Sahasrabuddhe, N. A., Mathur, P. P., Prasad, T. S. K., Kumar, P., Califano, J. A., Sidransky, D., Pandey, A., Gowda, H. and Chatterjee, A. (2016). Dysregulation of splicing proteins in head and neck squamous cell carcinoma. Cancer Biology and Therapy. 17, 219-229. [PubMed]
    • Subbannayya, T., Leal-Rojas, P., Barbhuiya, M., Raja, R., Renuse, S., Sathe, G., Pinto, S. M., Syed, N., Nanjappa, V., Patil, A. H., Garcia, P., Sahasrabuddhe, N. A., Nair, B., Guerrero-Preston, R., Navani, S., Tiwari, P. K., Santosh, V., Sidransky, D., Prasad, T. S. K., Gowda, H., Roa, J. C., Pandey, A. and Chatterjee, A. (2015). Macrophage migration inhibitory factor - a therapeutic target in gallbladder cancer. BMC Cancer. 15, 843. [PubMed]
    • Pawar, H., Chavan, S., Mahale, K., Khobragade, S., Kulkarni, A., Patil, A., Chaphekar, D., Varriar, P., Sudeep, A., Pai, K., Prasad, T. S. K., Gowda, H. and Patole, M. S. (2015). A Proteomic map of the unsequenced kala-azar vector Phlebotomuspapatasiusing cell line. ActaTropica. 152, 80-89. [PubMed]
    • Nanjappa, V., Renuse, S., Sathe, G. J., Raja, R., Syed, N., Radhakrishnan, A., Subbannayya, T., Patil, A., Marimuthu, A., Sahasrabuddhe, N. A., Guerrero-Preston, R., Somani, B. L., Nair, B., Kundu, G. C., Prasad, T. S. K., Califano, J. A., Gowda, H., Sidransky, D., Pandey, A. and Chatterjee, A. (2015). Chronic exposure to chewing tobacco selects for overexpression of stearoyl-CoA desaturase in normal oral keratinocytes. Cancer Biology and Therapy. 16(11), 1-11. [PubMed]
    • Pinto, S. M., Nirujogi, R. S., Leal-Rojas, P., Patil, A. H., Manda, S. S., Subbannayya, Y., Roa, J. C., Chatterjee, A., Prasad, T. S. K and Pandey, A. (2015). Quantitative phosphoproteomic analysis of IL-33 mediated signaling. Proteomics. 15, 532-544. [PubMed]
    • Kim, M. S., Pinto, S. M., Getnet, D., Nirujogi, R. S., Manda, S. S., Chaerkady, R., Madugundu, A. K., Kelkar, D. S., Isserlin, R., Jain, S., Thomas, J. K., Muthusamy, B., Leal-Rojas, P., Kumar, P., Sahasrabuddhe, N. A., Balakrishnan, L., Advani, J., George, B., Renuse, S., Selvan, L. D. N., Patil, A. H., Nanjappa, V., Radhakrishnan, A., Prasad, S., Subbannayya, T., Raju, R., Kumar, M., Sreenivasamurthy, S. K., Marimuthu, A., Sathe, G. J., Chavan, S., Datta, K. K., Subbannayya, Y., Sahu, A., Yelamanchi, S. D., Jayaram, S., Rajagopalan, P., Sharma, J., Murthy, K. R., Syed, N., Goel, R., Khan, A. A., Ahmad, S., Dey, G., Mudgal, K., Chatterjee, A., Huang, T. C., Zhong, J., Wu, X., Shaw, P. G., Freed, D., Zahari, M. S., Mukherjee, K. K., Shankar, S., Mahadevan, A., Lam, H., Mitchell, C. J., Shankar, S. K., Satishchandra, P., Schroeder, J. T., Sirdeshmukh, R., Maitra, A., Leach, S. D., Drake, C. G., Halushka, M. K., Prasad, T. S. K., Hruban, R. H., Kerr, C. L., Bader, G. D., Iacobuzio-Donahue, C. A., Gowda, H. and Pandey, A. (2014). A draft map of the human proteome. Nature. 509, 575-581. [PubMed]
    • Murthy, K. R., Goel, R., Subbannayya, Y., Jacob, H. K. C., Murthy, P. R., Srikanth, S. M., Patil, A. H., Sharma, R., Sahasrabuddhe, N. A., Parashar, A., Nair, B. G., Krishna V., Prasad, T. S. K., Gowda, H. and Pandey, A. (2014). Proteomic analysis of human vitreous humor. Clinical Proteomics. 11, 29. [PubMed]
    • Srinivasan, S., Patil, A. H., Verma, M., Bingham, J. L. andSrivatsan, R. (2012). Genome-wide Profiling of RNA splicing in prostate tumor from RNA-seq data using virtual microarrays. Journal of Clinical Bioinformatics. 2, 21. [PubMed]
    • Patil, A. H., Deshmukh, M., Singh, K. N., Srivastava, R., Swati, K. S., Verma, M., Gupta, S., Veeresh, S., Srivatsan, R. and Srinivasan, S. (2012). From data repositories to potential biomarkers: application to prostate cancer. Current Science. 102, 1111-1116. [PubMed]